MOTS-C: The Mitochondria-Derived Peptide and Cellular Energy Research
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Among peptides studied in cellular aging research, MOTS-C occupies a particular place: it is encoded directly by mitochondrial DNA rather than the nuclear genome, making it a unique subject for understanding mitochondria-nucleus communication.
Overview
MOTS-C belongs to the family of mitochondrial-derived peptides (MDPs). It has been studied for several years for its involvement in regulating cellular energy metabolism and its capacity to act as a retrograde signal between the mitochondria and the nucleus.
Proposed mechanism of action
Current research focuses on the activation of the AMPK (AMP-activated protein kinase) pathway by MOTS-C, a central regulator of cellular energy balance. This activation is studied in models exploring insulin sensitivity and metabolic glucose utilization.
Scientific research focus
- Metabolic homeostasis and AMPK signaling
- Research models mimicking physical exercise
- Cellular energy production and mitochondrial function
- Models of aging-related mitochondrial decline
Purity & quality standards
CELLOVATE applies strict internal standards to ensure consistency and reliability:
- High-purity peptide structure (≥99% HPLC)
- Independent third-party verification, batch by batch
- Batch-to-batch consistency
- Lyophilized form, nitrogen-sealed for stability
Storage & handling
MOTS-C is supplied as a lyophilized powder. Once reconstituted, it should be stored between 2 and 8°C and used within the timeframe indicated on the supplied certificate of analysis.
Research use only
MOTS-C is offered strictly as a research reagent for in-vitro and laboratory studies conducted by qualified professionals. It is not a drug, supplement, or cosmetic, and is not intended for human or animal use.
